Hesperocnide sandwicensis, the Hawai'i stingingnettle, is a rare species of nettle endemic to the island of Hawai'i.

Less than 1000 plants from only 3 occurrences are estimated to exist due to grazing pressure from invasive sheep, goats, and pigs.

Hesperocnide sandwicensis is an annual nettle, growing 20-60cm tall.

[3] Unlike other Hawaiian nettles which lost their ability to sting due to a lack of large herbivores, H. sandwicensis has retained this ability and its hairs can provide a painful sting if touched.

[4] Hesperocnide sandwicensis grows only in the understory of subalpine dry forests on the volcanic slopes of Mauna Kea, Mauna Loa, and Hualālai on the big island of Hawai'i.