It was founded in 1951 by Parmanand Deepchand Hinduja, in collaboration with the Massachusetts General Hospital, the main teaching hospital of Harvard Medical School, Boston.

[8][9] It has strategic partnerships with King's College London, Guy's and St Thomas' NHS Foundation Trust, Geneva University Hospitals, Stanford University, Henry Ford Health Systems to advance training, education and research.

[10][11][12][13][14] Hinduja Hospital, Mahim, is a not-for-profit institution, with at least 20% of its total capacity reserved for people from the economically weaker section.

[19][20][21] Hinduja National Hospital is a major referral centre in India for the 55 specialities:[22] It has plans to expand its nationwide capacity to 5,000 beds,[23][24][25] besides setting up radiology and pathology diagnostic centres, emergency ambulance services and pharmacy retail outlets across India.

[27][28] It is also working with the Biomedical Engineering and Technology (incubation) Centre (BETiC) of IIT Bombay to co-develop and commercialise biomedical devices.