4BKX, 5ICN3065433759ENSG00000116478ENSMUSG00000028800Q13547O09106NM_004964NM_008228NP_004955NP_032254Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

[5] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression.

The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex.

It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation.

Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.