[5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

[7] AMP-activated protein kinase regulation of the glucose transporter GLUT4 occurs by phosphorylation of HDAC5.

[8] HDAC5 is involved in memory consolidation and suggests that development of more selective HDAC inhibitors for the treatment of Alzheimer's disease should avoid targeting HDAC5.

[10] HDAC5 overexpression in urothelial carcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (EMT)[11] Histone deacetylase 5 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.