The series saw the returns of Oliver Valentine (James Anderson), Henrik Hanssen (Guy Henry), and Essie Harrison (Kaye Wragg).
Louise Delamere (Colette Sheward) made her exit in the fourth episode, later followed by Jules Knight (Harry Tressler) and Niamh McGrady (Mary-Claire Carter).
Michael Thomson (Jonny Maconie) departed in episode 27, along with Rosie Marcel (Jac Naylor), who made a temporary departure to have her first child.
[2] The series saw the return of Hari Dhillon as Michael Spence for six episodes, while Debbie Chazen was introduced as consultant Fleur Fanshawe for a three-month guest stint.
[1] The second episode of the series saw a guest appearance from actress Wanda Ventham as Myrtle McKee, a patient who is treated by Dominic Copeland (David Ames).
[7] The fourth episode also saw guest appearances from Antony Costa and Georgia Moffett, as Matthew Pendleton and Briony Whitman, following their debuts in Holby City's sister show Casualty on 1 November 2014.
[11] This series saw the returns of Henrik Hanssen (Guy Henry), Oliver Valentine (James Anderson) and Essie Harrison (Kaye Wragg).
[14][15] The series' first standalone episode was broadcast on 6 January 2015, and focused on the Effanga sisters Mo (Chizzy Akudolu) and Adele (Petra Letang).
[23][24] On 26 May 2015, it was announced former EastEnders actress Gillian Wright was to guest star as "troublesome" patient Lydia Rathbone during the episode broadcast on 2 June.
"[28] The first episode of the series attracted an overnight audience of 4.64 million, with a 22.4% share in its time slot, making it the show's highest rating since 13 May 2014.
[34] The show also received a nomination in the Soaps and Continuing Series category at the Mind Media Awards for Zosia's bipolar storyline.
[35] The fiftieth episode, "At First I was Afraid" by Julia Gilbert earned a nomination in the Best Long Running TV Series category at the 2016 Writers' Guild of Great Britain Awards.