The Holmes Regional Medical Center is a not-for-profit hospital operated by Health First.

It is a 514-bed facility, including the only level II trauma center in Brevard County.

[4] In 1953, James E. Holmes was elected to the Hospital's Board of Governors, serving as its president for the next 25 years, until 1978.

In 2011, it had 55.1% of its admissions through the emergency room, less than any other hospital in Brevard and below the state average of 61.6%.

[5] In the year ending June 2010, there were 899 hospitalizations for angioplasty, the most selected surgery.