[3] In 2011, All Children's Hospital became the first center outside the Baltimore-Washington, D.C., area to integrate with the Johns Hopkins Health System.

As the threat of polio decreased, hospital leaders planned for a future that included a wider variety of services.

[13] Johns Hopkins All Children's has 11 outpatient care centers in six counties on Florida's west coast and affiliations and collaborations with community and regional hospitals where Johns Hopkins All Children's physicians and protocols have direct impact on patient care.

Several other AdventHealth locations in Pasco, Hillsborough and north Pinellas counties follow Johns Hopkins All Children's clinical pediatric protocols in their emergency centers.

Johns Hopkins All Children's also collaborates with such hospitals as Sarasota Memorial, Brandon Regional, St. Petersburg General and others to provide specialty care to their patients.

The surgeons in the pediatric heart surgery program made serious mistakes and procedures went wrong in unusual ways.

[18] The problems started after the departure of program leader Dr. James Quintessenza after hospital officials had disputes with him.

The surgeons that were hired to replace Quintessenza were lackluster in their techniques and mortality rates tripled in a period of two years.

[25] Administrators have announced that the hospital will implement new policies and structural changes to address the core issues that allowed the troubled heart program to continue.

Doctors at the hospital suspected Maya was being medically abused by her mother, Beata Kowalski, as a symptom of Munchausen by proxy.

On November 9, 2023, a Florida jury found in favor of the Kowalski family and awarded them $261 million in damages after 3 days of deliberations.