Tampa General Hospital is the primary teaching affiliate of the Morsani College of Medicine of University of South Florida.

[3] TGH also features the area's only ACS designated level I adult and pediatric trauma center[4] and has a rooftop helipad to handle medevac patients.

[8] Local legend has it that the placement of what was originally named Tampa Municipal Hospital on Davis Islands was decided in a bunker of the Palma Ceia Country Club golf course.

The city had considered expanding the existing George Keller Memorial Hospital, located at 306 North Boulevard in what had been the grounds of the Tampa Bay Hotel, but had found such expansion unworkable.

Tampa General Hospital is a level one trauma center, with a five-helicopter fleet, serving 23 counties.

[18] As of 2021 Tampa General Hospital has placed nationally in 5 ranked pediatric specialties on U.S. News & World Report.

The impact of Hurricane Elena caused the hospital's main generator plant to be moved out of its previous location in the basement to a higher location, reducing the risk of it being rendered in-operational by flooding, but the hospital site is still vulnerable to the Davis Islands bridges being washed out during a hurricane.

[23] The fence the hospital uses can withstand storm surges of 15 feet (4.6 m) and wind speeds of 130 miles (210 km) per hour, which can handle a category 3 hurricane.