Holy Cross Church is a Roman Catholic church located at 329 West 42nd Street between Eighth and Ninth Avenues in the Hell's Kitchen neighborhood of Manhattan, New York City, near Times Square and across the street from the Port Authority Bus Terminal.

[5] The Holy Cross School, located behind the church at 332 West 43rd Street, was built in 1887 to a design by Lawrence J.

[4] Since 1900, Holy Cross Church has worked with politicians, police and community groups to combat poverty, crime and drugs in the neighborhood.

[7] Holy Cross Church has been staffed by priests of the Order of Friars Minor Capuchin since the 2015 merger.

[8] The exterior of Holy Cross Church shows a red brick facade with flanking twin towers in an Italianate Gothic form.

Holy Cross Church operates Crossroads Food Pantry and Harvesters Soup Kitchen (alternate Saturdays) serving the poor and hungry.

It also conducts an evangelical program named LAMP Missionary for the assistance of local residents and passers-by who wish to receive religious counseling.

Duffy served as Chaplain of the "Fighting Irish" 69th New York Regiment during World War I, and was decorated for his activities.