The Homburg–Rohrbach line, now part of the mainline between Mannheim and Saarbrücken, opened to traffic on 1 January 1904.

31 years later, on 6 March 1991, the first EuroCity service, the EC 56: Goethe, stopped in Homburg.

In the summer and autumn of 1991 the tracks were adapted for the operation of Intercity-Express trains, so that in January 1992, the first ICE (Type 1) ran to Homburg.

In the following years, the station and the environment was modernised, including by the installation of electronic noticeboards for outgoing train and bus connections, lifts on all tracks and electronic noticeboards on platforms.

There is also a siding on the line to Bexbach connecting to the site of the former army depot in Homburg.