The Honda RC212V is a Japanese motorcycle created for road racing in the 800 cc (49 cu in) MotoGP series.

The model name designates the following: The RC212V features an 800 cc (49 cu in), liquid-cooled, four-stroke, DOHC 4-valve V4 to power an all-new chassis built with mass centralization and handling as top priority.

Dani Pedrosa and Nicky Hayden rode the factory-backed versions, while the customer machines were ridden by Marco Melandri, Toni Elías, Carlos Checa, and Shinya Nakano.

Before the racing season started in 2007, Melandri was quoted as saying, "In the past few tests I've seen a big progression with Pedrosa's bike, but we're still waiting for new parts from Honda.

"[2] After a few rounds, Honda riders did not achieve the results expected, leading HRC chief Satoru Horiike to admit that they made a mistake in the motorcycle's development.

[3] Melandri decided to ride with the Ducati team in 2008[4] and Pedrosa's dissatisfaction led to rumors that he was leaving Honda.

[5] Towards the end of 2007, however, there were signs of improvement, with the Repsol Honda team taking the last five pole positions of the season and Pedrosa winning the last round at Valencia.

[16] An electronic problem at the subsequent Assen round caused Hayden to run out of fuel just before the line, allowing Colin Edwards to come around him and take the remaining podium position.

"[26] Before Round 6 at Catalunya, Dovizioso expressed frustration that Pedrosa would be given priority in the post-race test, feeling that the Spaniard's poor physical condition would not lead to a productive evaluation.

Pedrosa experienced speed wobbles down the front straight, and Honda determined that they had committed a mistake in the design of the chassis, and that by trying to make the bike easier to ride, they made it too flexible.

[40][41] Pedrosa later said and Honda confirmed that a fuel sensor problem slowed down the RC212V in the final laps and may have cost him the victory at Jerez.

[52] Honda won the manufacturer's championship with 13 wins between Stoner's ten and Pedrosa's three, and never finished lower than second in race results.