The London and South Western Railway opened the calling point on 1 February 1850 on completion of the bridges and embankments at Isleworth station.

[2] After this point the main commercial businesses of Hounslow and landmark buildings moved westward along Staines Road, Hounslow's fledgling high street and a major then-artery serving London and the south-west to reflect the new position of the railway station serving the nascent town.

The Victoria County History series local historian Susan Reynolds, in 1962, noted "...it was not until the very end [of the nineteenth century] that there were any houses to speak of to the south of the station.

A total of £650,000 was spent for alterations over four months in the early 2010s including a larger booking hall and toilet, access for people with disabilities and low-energy, semi-automated lighting.

On Sundays, the service is reduced to hourly in each direction and westbound trains run to and from Woking instead of Weybridge.