[1] HPyV6 was first discovered in 2010 by rolling circle amplification, a genetic technique that efficiently amplifies and detects circular DNA, such as a polyomavirus genome.

[1] In the 2015 taxonomic update to the polyomavirus group, the International Committee on Taxonomy of Viruses classified HPyV6 as a member of the genus Deltapolyomavirus.

[1][3][4][5][6] The age-dependent pattern of seroprevalence featuring a decline at around six months old is consistent with the transmission of maternal antibodies.

[7] Another similar study reported HPyV6 DNA prevalence at around 30%, with 24% showing persistent viral shedding over time.

[8] HPyV6, and the closely related HPyV7, have been linked to skin rashes known as pruritic and dyskeratotic dermatoses in immunocompromised patients in case reports, though a causal association has not yet been established.