Hypostomus margaritifer[1] is a species of catfish in the family Loricariidae.

It is native to South America, where it occurs in the upper and middle Paraná River basin.

The species reaches 33 cm (13 in) in total length and is believed to be a facultative air-breather.

[2] It is known to be syntopic with other loricariid species in the genus Hypostomus, including Hypostomus ancistroides, H. denticulatus, H. heraldoi, H. iheringii, and H.

[4] This article relating to Hypostominae is a stub.