The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family.

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.

[5] This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.

It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.