[5] IL12RB2 orthologs[6] have been identified in all mammals for which complete genome data are available.

The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.

In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation.

[7] The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

[5] Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.