The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family.

This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction.

IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells.

This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.

[5] This article incorporates text from the United States National Library of Medicine, which is in the public domain.