[5][6][7] Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein.

This gene encodes an interleukin 1 receptor accessory protein.

Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.

[7] IL1RAP has been shown to interact with TOLLIP[8] and Interleukin 1 receptor, type I.

[9] This article on a gene on human chromosome 3 is a stub.