2B5I, 2ERJ, 3QAZ, 4GS7356016185ENSG00000100385ENSMUSG00000068227P14784P16297NM_000878NM_001346222NM_001346223NM_008368NP_000869NP_001333151NP_001333152NP_032394Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene.

The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction.

Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

Activation of the receptor increases proliferation of CD8+ effector T cells.

[6] IL2RB has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.