[5] The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9).

The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.

Genetic studies suggested an association of this gene with the development of asthma.

Alternatively spliced transcript variants encoding distinct isoforms have been reported.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.