[5][6][7] IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis.

It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis.

[5] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A.

[8] This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

[5] This article incorporates text from the United States National Library of Medicine, which is in the public domain.