72 kDa inositol polyphosphate 5-phosphatase, also known as phosphatidylinositol-4,5-bisphosphate 5-phosphatase or Pharbin, is an enzyme that in humans is encoded by the INPP5E gene.
Its intracellular localization is the primary cilium, a small organelle involved in signal transduction.
INPP5E plays a role in hydrolyzing PtdInsP3 produced in response to various growth factors such as PDGF.
Inactivation of the mouse INPP5E gene decreases primary cilia stability, leading to a multiorgan disorder, including absence of eyes, polydactyly, exencephaly and renal cysts.
[4] This article incorporates text from the United States National Library of Medicine, which is in the public domain.