The series deals with Gwen Dylan (née Gwendolyn Price), a revenant gravedigger in Eugene, Oregon and her friends Ellie, a 1960s ghost, and Scott, a were-terrier.

Vampires, parental fights, zombies, romance triangles, cabin fever, delayed apocalyptic battles and technical support are just some of the situations under-prepared, heavily manipulated, not-quite-human twenty-somethings have to deal with.

In November 2013, The CW ordered a pilot episode named after the comic from writer/producers Rob Thomas and Diane Ruggiero-Wright, who developed the property as a supernatural procedural drama for the network.

The series picks up five months after the incident; Liv now works as a King County morgue assistant, along with Dr. Ravi Chakrabarti played by Rahul Kohli, which provides her with a steady supply of brains from murder victims which she must eat in order to retain her intelligence.

A side effect of eating brains is that she experiences the deceased's memories in the form of visions, and temporarily absorbs their habits and abilities which she uses to assist in solving crimes.