It is a radial route that travels in a south to north direction from central Osaka to Itami Airport and Ikeda, with a length of 14.2 kilometers (8.8 mi).

The southbound exit ramp to the area is the Ikeda Route's most notable feature, an exit ramp that passes through the Gate Tower Building, taking up part of the building's fifth, sixth, and seventh floors.

[2][3] From there it travels northwest from central Osaka, crossing the Yodo River.

Approaching the vicinity of Itami Airport, it slowly begins to curve to the northwest again.

The expressway then begins paralleling the Ina River as it travels north toward Kawanishi, once again briefly switching to the opposite shore of the river in Hyōgo Prefecture, before returning into Osaka.