The Yamatogawa Route (大和川線, Yamatogawa-sen), signed as Route 6, is one of the routes of the Hanshin Expressway system serving the Keihanshin area in Kansai, Japan.

It travels in a west to east direction in Osaka Prefecture, from the Bayshore Route, in Sakai to the Matsubara Route in Matsubara, with a total length of 9.7 kilometers (6.0 mi).

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