It travels in a southwest to northeast direction in Osaka and the neighboring city of Moriguchi, from the Loop Route, in the Kita ward of Osaka, to National Route 1 in the city of Moriguichi.

Heading north, it crosses over National Route 1 near Minami-morimachi Station.

It then crosses into the Miyakojima ward, where it begins closely paralleling the south bank of the Yodo River, a path the expressway will follow to its northern terminus.

[1] A "mini" parking area with toilets and vending machines is placed on the entrance ramp from National Route 163.

[1] Maintenance and construction of the existing and new routes of the Hanshin Expressway began in 1967 in preparation for the Expo '70, a world's fair held in Suita, Osaka, between 15 March and 13 September 1970.