It travels in a north to south direction from the Chūō ward of Osaka, beginning at a junction with Sennichi-mae-dōri, to National Route 26 in the city of Sakai.

The Sakai Route travels in a north to south direction from the Chūō ward of Osaka, beginning as a one-way highway at junction with Sennichi-mae-dōri.

From there, it briefly parallels the Hanshin Namba Line to Shiomibashi Station where the expressway curves to the south.

[3] Construction of the Nishi-Osaka Route began in 1967 in preparation for the Expo '70 held in the nearby city of Suita.

[4] Another 1.2-kilometer-long (0.75 mi) section of the expressway that runs within the confines of the Loop Route in central Osaka was opened in 1972.