The Yodogawa-Sagan Route (淀川左岸線, Yodogawa-Sagan-sen), signed as Route 2, is one of the routes of the Hanshin Expressway system serving the Keihanshin area in Kansai, Japan.

It travels in a west to east direction in Konohana-ku, Osaka, from the Bayshore Route, near Universal Studios Japan to the Kobe Route, with a total length of 5.6 kilometers (3.5 mi).

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