ISWI (Imitation SWItch) is one of the five major DNA chromatin remodeling complex types, or subfamilies, found in most eukaryotic organisms.
However, the chromatin remodeling activities of ISWI and SWI/SNF are distinct and mediate the binding of non-overlapping sets of DNA transcription factors.
[3] The protein ISW1 is the first ATPase subunit which has been isolated in the ISWI chromatin remodeling family in the fruit fly Drosophila.
Inside the CHRAC complex, ISWI catalyzes the inverse reaction, moving nucleosomes from the extremities to the center.
[5] The first figure in this paper shows three AFM images from where single DNA interacting with ISWI was deposed on mica surfaces.