The Church of the Immaculate Conception is a parish church in the Roman Catholic Archdiocese of New York, located at 414 East 14th Street, near First Avenue, Manhattan, New York City, and previously at 505 East 14th Street.

[3] The school opened in 1864, staffed by the Sisters of Charity of New York; the Christian Brothers arrived in 1880 and assumed instruction of the boys.

By the tenure of Monsignor John Edwards in 1875, Immaculate Conception was the largest parish in the city.

[6] The following decades saw a diminishing number of parishioners as members of the congregation moved to other parts of the city.

[1] On February 16, 2023, the Archdiocese of New York announced that the school would close at the end of the current academic year due to falling enrollment levels and pandemic-related issues.