[3] The chain is known for its version of St. Louis-style pizza, which is common in the area and features provel cheese—a combination of cheddar, Swiss, and provolone with a low melting point and gooey texture.

Recognizing an opportunity, the couple decided to establish a pizza parlor that offered delivery and soon began searching for a location in The Hill neighborhood of St.

Ed Imo continued to work as a tile setter during the day while managing pizza preparation in the evenings, introducing the square slice style.

Margie Imo handled customer service and food preparation, using a repurposed tackle box as the cash register.

[2][6] In 2016, Imo's Pizza relocated its corporate headquarters and distribution operations to a new facility in downtown St. Louis, which includes a 72,000-square-foot warehouse and a 10,000-square-foot office space.