The western section begins at SR 63 and heads east towards Jasonville.

Northwest of Worthington SR 48 ends at State Road 157.

[3] The middle section of SR 48 begins at an intersection with State Road 43 and SR 48 heads east towards Bloomington.

The eastern terminus of this section is at an interchange with Interstate 69 and State Road 45 (SR 45) in Bloomington.

[4] The eastern section begins at an intersection with State Road 229 and SR 48 heads east from that intersection.