Despite its proximity to Interstate 69 being within neighboring Gibson and Vanderburgh Counties, the two routes have no relation to each other.

The road turns east onto SR 62 and the two routes pass through downtown Mount Vernon.

The highway makes a sharp curve heading northeast towards Griffin where it terminates at Interstate 64 (I–64).

[7] The NHS is a network of highways that are identified as being most important for the economy, mobility and defense of the nation.

This measurement is a calculation of the traffic level along a segment of roadway for any average day of the year.

[13] Eventually it was connected to Interstate 64 at the Griffin exit and rerouted to bypass New Harmony.

In the late 1990s, a number of relocations and widenings were made to the highway in order to increase its traffic capacity, including being rerouted onto the new William Keck Bypass around the eastern side of Mount Vernon.

These improvements allow for coal trucks and other industrial vehicles to reach Mount Vernon and its Port of Indiana from Interstate 64 much easier than with the previous route.