[1] The series was developed in early 2012 by screenwriter, Suzette Doctolero (the writer behind such epic series as Encantadia, Etheria: Ang Ikalimang Kaharian ng Encantadia and Amaya) and under the supervisions of historians: Dr. Vic Villan of the University of the Philippines Diliman (who was also the consultant for Amaya) and Dr. Rolando Borrinaga; and GMA Entertainment TV creative heads, Jake Tordesillas and Jun Lana.

GMA Network's Vice President for Entertainment TV, Lilybeth G. Rasonable said that "Indio was really made for him.

"[17][18] Actor Alden Richards signed on to play the teenage version of the title character while Vincent Magbanua auditioned and successfully cast as the younger Malaya.

[19] In August 2012, Maxene Magalona was added to the cast, wherein her role had previously been offered to Sunshine Cruz.

Michael de Mesa and Jackie Lou Blanco were signed on to portray the antagonist roles of Juancho and Victoria Sanreal.

Some of the notable actors, that appeared and portrayed important characters, were Mark Gil, Ramon Christopher, Aljur Abrenica, Katrina Halili and Ryan Eigenmann.

De Guzman also worked in tandem with writer Vim Nadera in creating other themes like: "May Laya" (transl.

"[34] The Philippine Star's entertainment columnist, Ricky Lo felt that the series "It's almost as big as a movie.

"[17] Bibsy M. Carballo of The Philippine Star said that "If there were to be a historical drama-fantasy series that would reach epic proportions, it would have to be Indio!

"[35] Entertainment columnist and Startalk host, Lolit Solis praised the ensembles' acting performances, including Vince Magbanua's, the 10-year-old Palaweño who played young Malaya/Simeon.

[36] Isah V. Red of Manila Standard Today and Nestor Cuartero of Tempo praised Revilla's acting performance.

Red said that "He isn't too far behind in scenes that have actors like Michael de Mesa, Chinggoy Alonso, Ronnie Lazaro, and Jackielou Blanco.

Viewers can easily discern each of the characters they are watching due to the clear portrayal by the actors who fittingly tint their roles with the proper tones, and Revilla, though not formally schooled in acting, displays keen understanding of characterization.

"[37] While Cuartero said "He proves beyond doubt that aside from being an "action star", he is also very competent in drama, investing the part with his heroic presence.

"[38] Writer-director Ronald Carballo impressed with the performances of Revilla, De Mesa, Jennylyn Mercado, Sheena Halili and Vaness del Moral, said that "With the great flow of the story, wonderful performances and excellent cinematography, I am hooked now on the show, as in every night.

"[42] Blogger Neil Celeste Rara described the show as "thrilling and visually captivating", stating "While the ratings war remains to be tough and the battle is fought day by day, the people behind this wonderful series have a reason to sleep soundly at night, for they not only have done their jobs well, they have also created a piece of art that viewers will always remember.