María Josefa Carmela of Spain (6 July 1744 – 8 December 1801) was a Princess of Naples and Sicily by birth.

Born and raised in Naples, she arrived in Spain with her family in October 1759, at age fifteen.

Her parents' fourth child, at the time of her birth she had an older sister María Isabel Ana (1743–1749).

Her parents were a devoted couple; her mother Maria Amalia of Saxony died barely a year after the family's arrival to Spain.

[1] She died at the Royal Palace of Madrid aged 57, before her brother Charles IV lost the throne and was exiled in 1808.