Princess Maria Isabella of Naples and Sicily (2 December 1793 – 23 April 1801) was a member of the House of Bourbon.

She was the youngest child and daughter of Ferdinand I of the Two Sicilies and his wife, Maria Carolina of Austria.

Her father was Ferdinand, Duke of Calabria,[1] the third son and ninth child of King Charles III of Spain and Queen Maria Amalia of Saxony.

Her brothers included the future King Francis and Leopold, Prince of Salerno.

Another sister was the Queen of the French as the wife of Louis Philippe I and the youngest was the future Princess of Asturias.