Neural circuitry has been shown to connect different sites of stimulus to other regions of response including other subdivisions and also other frontal gyri.

The results were significant to support that there was a pattern of left lateralization for each of these tasks all activating the Perisylvian fissure network, with some general localized areas for phonology and arithmetic.

The pars opercularis (BA44) is involved in language production and phonological processing due to its connections with motor areas of the mouth and tongue.

Characteristics of Broca's aphasia include agrammatic speech, relatively good language comprehension, poor repetition, and difficulty speaking mostly uttering short sentences made up mostly of nouns.

The left IFG has also been suggested to play a role in inhibitory processes, including the tendency to inhibit learning from undesirable information.

For example, transcranial magnetic stimulation to the left IFG has been shown to release such inhibition, increasing the ability to learn from undesirable information.

Disruption of activity of this area with transcranial direct-current stimulation (tDCS) leads to change in risk attitudes, as behaviorally demonstrated by choices over risky outcomes.