An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in pre-mRNA splicing factors.

[2][7] Interchromatin granules are structures undergoing constant change, and their components exchange continuously with the nucleoplasm, active transcription sites and other nuclear locations.

[2][7][8] Research on dynamics of interchromatin granules has provided new insight into the functional organisation of the nucleus and gene expression.

Interchromatin granule clusters (IGCs) may represent small nuclear ribonucleoproteins (snRNPs) that have completed their maturation process and can be supplied to nearby areas containing perichromatin fibers where splicing is taking place.

[2] The maturation of snRNPs takes place in part in Cajal bodies, and IGCs may donate splicing factors to the snRNP.