Interferon-inducible GTPase 5

[5][8] It is on the forward strand and is upstream of Phospholipase A2 Inhibitor and Ly6/PLAUR Domain-Containing Protein-Like (LOC105372412) and downstream of Nonsense Mediated mRNA Decay Factor (SMG9).

IRGM, or immunity related GTPase M, is associated with intracellular defense.

[11] IRGC is predicted to have evolved more rapidly than cytochrome c and β-hemoglobin when comparing the percent identity of the same species for each gene over 500 million years.

[12] The most common transcript for IRGC is 1596 base pairs long and has the accession number NM_019612.

[14][15][16] Interferon-inducible GTPase 5 is 463 amino acids long, has a molecular weight of 50.3 kDa, and a predicted isoelectric point of 5.22.

[29] Leydig cells, spermatogonia, and preleptotene spermatocytes were reported to have low expression.

[29] There was low to medium expression observed with both antibodies in the duodenum, small intestine, appendix, and kidney.

[31][32] There is unknown clinical association with transcript variations both in the 3' and 5' UTR and within the coding region.

NCBI IRGC gene location on chromosome, includes nearby genes.
Sample of eukaryotes with orthologous sequences for IRGC, includes sequence identity, estimated date of divergence, and color coded for animal class.
For three genes - IRGC, beta-hemoglobin, and cytochrome c, several distant orthologs of the same type were compared to human sequences for their percent identity. This was plotted and compared to time in millions of years. IRGC is seen to have diverged more rapidly than the other genes.
NCBI X-ray crystallography structure for ITQD_A, Chain A for Interferon-inducible GTPase found in mice. It is predicted to be similar in structure to interferon-inducible GTPase 5.