Interleukin-3 receptor

The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

It can be found on basophils and pDCs as well as some cDCs among peripheral blood mononuclear cells.

CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.

[1] Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN.

Quaternary structure of the CD123 protein