The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family.

This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling.

IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.

Two alternatively spliced transcript variants encoding the same protein have been reported.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.