I-110 provides access from I-10 to the Bridge of the Americas, which spans the Rio Grande to connect with Avenida Abraham Lincoln in Ciudad Juárez, Mexico.

[4] The route proceeds north, crossing over all six lanes of Loop 375 (Cesar E. Chavez Border Highway) and divided Delta Drive.

The roadway's mainlanes proceed northward through the El Paso BOTA Port of Entry, where each vehicle is searched by the U.S. Border Patrol.

The route continues north, traveling parallel to Chamizal National Memorial, before splitting off and reaching an interchange with US 62 (East Paisano Drive).

[9] The Interstate is almost entirely unsigned; the only signage showing its existence is on two overhead signs just beyond the El Paso BOTA Port of Entry going northbound.