The road comes to a southbound exit and northbound entrance with SR 2089, a four-lane freeway that heads south to an intersection with PA 10/PA 23 in Morgantown.

The route reaches a diamond interchange with PA 724 and passes over Norfolk Southern Railway's Harrisburg Line #1 and the Schuylkill River Trail as it heads west of industrial areas.

At the time of its opening, the highway was originally known as Interstate 180 (I-180) or the "Reading Spur" when the Pennsylvania Turnpike was designated as I-80S, but was redesignated to its present-day number in 1964 when I-80S became I-76.

[5]Prior to 1996, motorists wanting to get to I-176 from the Pennsylvania Turnpike (I-76) had to travel through Morgantown on PA 10 and then enter I-176 northbound to Reading at a traffic light, similar to that found on I-70 in Breezewood.

Since 1996, a replacement Pennsylvania Turnpike interchange and a new stretch of I-176 have eliminated the need to travel through Morgantown, with the old section, now a spur numbered SR 2089,[3] still maintained as ramps leading to and from exit 2.