It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania.

It is the longest beltway with an Interstate highway designation in the United States,[2] enclosing an area of over 250,000 acres (100,000 ha).

I-275 is also known as the Cincinnati Bypass and officially known as the Donald H. Rolf Circle Freeway in Ohio, after a state senator,[4] but locals rarely use these names, instead simply referring to it as "275" or "the loop".

[5] The section in Clermont County is also designated as the Staff Sergeant Matt Maupin Veterans Memorial Highway.

When the concurrency ends, I-275 has an intersection with State Route 126 (SR 126, Ronald Reagan Cross County Highway).

I-275 passes over the Little Miami River, entering Clermont County, where it is officially named in honor of Keith Matthew Maupin, a local soldier killed during the Iraq War.