Interstate 375 (I-375) in St. Petersburg, Florida, also known as North Bay Drive, is a 1.2-mile-long (1.9 km) spur route from I-275 into downtown.

[2] I-375 was originally planned as a much longer state highway, extending west of I-275 and following a CSX rail line toward a proposed toll road near Clearwater.

The cancelation of the rest of I-375 eventually resulted in US Highway 19 (US 19) between SR 694 (Gandy Boulevard) and the Pinellas–Pasco county line being upgraded to freeway standards.

On March 28, 2007, a tanker entering I-375 east from I-275 south's left exit lost control and hit the retaining wall, catching fire and burning for several hours.

FDOT placed signs along I-275 south, indicating the left exit onto I-375, due to this, as well as other fatal incidents, that have occurred on the interchange.