This can be disorienting for traffic wishing to continue south on US 281 from I-69C toward downtown Pharr and Hidalgo or north from the same; the Texas Department of Transportation (TxDOT) is currently working to complete the interchange.

I-69C provides access to Farm to Market Road 3461 (FM 3461; Nolana Loop) via a single northbound offramp (exit 1E) before coming to its first full diamond interchange, with Business US 281-W (Bus.

US 281-W on the northern edge of town, I-69C leaves Edinburg, skirting the small community of Faysville on its western flank before terminating at its overpass over FM 490 (exit 17).

The Federal Highway Administration (FHWA) approved the designation for the Lower Rio Grande Valley Segment on May 24, 2013,[3] and the Texas Transportation Commission followed suit on May 30, 2013.

[6] As of July 2021[update], the cluster consisting of the recently designated portions of I-69C, I-69E, and I-2 in the Rio Grande Valley is not connected to the national Interstate network.

This situation is slated to be remedied by scheduled projects to complete I-69E along US 77 between Raymondville and Robstown and the southern end of the previously signed portion of the I-69 corridor connecting with I-37 west of Corpus Christi.