[1] These areas are more susceptible to irritation and subsequent infection due to factors that promote skin breakdown such as moisture, friction, and exposure to bodily secretions and excreta such as sweat, urine, or feces.

[1] Areas of the body which are more likely to be affected by intertrigo include the inframammary fold, intergluteal cleft, armpits, and spaces between the fingers or toes.

[1] The term "intertrigo" commonly refers to a secondary infection with bacteria (such as Corynebacterium minutissimum), fungi (such as Candida albicans), or viruses.

Moisture-wicking textiles designed for skin folds are also increasingly recommended due to their ability to wick away moisture, promote evaporation, reduce friction, and often provide antimicrobial properties through embedded silver.

[3][4] Daily skin fold hygiene, including cleansing with a pH-balanced cleanser (avoiding alkaline soaps) and thorough drying, is commonly advised.

Breast reduction can be beneficial for women with macromastia, and post-bariatric patients with excess skin folds may also benefit from body contouring procedures to reduce skin-on-skin contact and improve hygiene.