[1] All rail services to and from the station are operated by BLS AG, a Swiss company.

The station is situated at Via Stazione, immediately to the south of the southern portal of the Simplon Tunnel, which passes underneath the border between Switzerland and Italy.

The village of Iselle, which gave its name to the station, is about 1 km (0.62 mi) upstream on the river Diveria, towards the Simplon Pass.

The station was opened on 1 June 1906, upon the inauguration of the Brig–Domodossola railway, including the Simplon tunnel.

[2] A monument in memory of the deceased workers of the Simplon Tunnel was erected on 29 May 1905.