The Iskaskunikaw River is a tributary of the Pauschikushish Ewiwach River in Regional County Municipality (RCM) of Eeyou Istchee James Bay (municipality), in the administrative region of Nord-du-Québec, Canadian province of Quebec, Canada.

The Iskaskunikaw River hydrographic slope is served by the northern route from Matagami to 3.0 kilometres (1.9 mi) South of the mouth of the head lake of the Iskaskunikaw River.

The surface of the river is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

From there, the current flows to the northwest, then to the northeast, and flows to the South shore of Dana Lake (Eeyou Istchee Baie-James), which empties into a bay on the West bank of Evans Lake.

The toponym "Iskaskunikaw River" was formalized on October 5, 1982 at the Commission de toponymie du Québec[3] Download coordinates as: