The Kakaskutatakuch River is a tributary of the Iskaskunikaw River in Regional County Municipality (RCM) of Eeyou Istchee James Bay (municipality) in the area of the Nord-du-Québec, Canadian province of Quebec, in Canada.

The surface of the river is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

From there, the current flows northward to the Pauschikushish Ewiwach River, which flows northwest and then to the northeast, and empties into the South shore of Dana Lake (Eeyou Istchee Baie-James) which flows into a bay on the west bank of Evans Lake.

The mouth of the Kakaskutatakuch River is located at: Of Cree origin, the toponym "Kakaskutatakuch brook" means: ‘’the brook with beetles".

The toponym "Kakaskutatakuch River" was formalized on October 5, 1982, at the Commission de toponymie du Québec.